Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 1.00 |
| ▸ | FLT1 | P17948 | 8/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 6/20 | 1.00 |
| ▸ | FLT4 | P35916 | 4/20 | 1.00 |
| ▸ | FGFR2 | P21802 | 1/20 | 1.00 |
| ▸ | FGFR4 | P22455 | 1/20 | 1.00 |
| ▸ | FGFR3 | P22607 | 1/20 | 1.00 |
| ▸ | EGFR | P00533 | 4/20 | 0.72 |
| ▸ | RET | P07949 | 7/20 | 0.69 |
| ▸ | KIF5B | P33176 | 6/20 | 0.69 |
| ▸ | RAF1 | P04049 | 1/20 | 0.63 |
| ▸ | BRAF | P15056 | 1/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.59 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5958891 | 0.92 | KDR (0.84) | KDRFLT1FGFR1FLT4FGFR2 | |
| SCHEMBL5958924 | 0.91 | KDR (0.83) | KDRFLT1FGFR1FLT4FGFR2 | |
| Hydrochloric Acid SCHEMBL7215129 | 0.91 | KDR (0.83) | KDRFLT1FGFR1FLT4FGFR2 | |
| Hydrochloric Acid SCHEMBL7211029 | 0.91 | KDR (0.83) | KDRFLT1FGFR1FLT4FGFR2 | |
| Hydrochloric Acid SCHEMBL7211044 | 0.90 | KDR (0.82) | KDRFLT1FGFR1FLT4FGFR2 | |
| SCHEMBL7211043 | 0.89 | KDR (0.84) | KDRFLT1FGFR1FLT4FGFR2 | |
| Hydrochloric Acid SCHEMBL7215782 | 0.88 | KDR (0.82) | KDRFLT1FGFR1FLT4FGFR2 | |
| SCHEMBL5958975 | 0.88 | KDR (0.77) | KDRFLT1FGFR1FLT4FGFR2 | |
| Hydrochloric Acid SCHEMBL7215089 | 0.87 | KDR (0.76) | KDRFLT1FGFR1FLT4FGFR2 | |
| SCHEMBL5958913 | 0.86 | KDR (0.76) | KDRFLT1FGFR1FLT4FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | claimed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | claimed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | claimed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | claimed |
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |