Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13776174 | 0.90 | ATR (0.44) | ATRAPPS1PR3CYP17A1SYK | |
| SCHEMBL14146034 | 0.90 | ATR (0.41) | ATRAPPS1PR3CYP17A1SYK | |
| SCHEMBL17616118 | 0.87 | ATR (0.42) | ATRAPPS1PR3CYP17A1SYK | |
| SCHEMBL25793113 | 0.85 | SYK (0.44) | ATRCYP17A1SYKLCKGAA | |
| SCHEMBL28203044 | 0.83 | SYK (0.40) | ATRCYP17A1SYKLCKCA12 | |
| SCHEMBL22314427 | 0.83 | LCK (0.45) | ATRCYP17A1SYKHTTLCK | |
| SCHEMBL26429672 | 0.81 | ATR (0.41) | ATRCYP17A1SYKLCKNPC1 | |
| SCHEMBL30937702 | 0.80 | CYP17A1 (0.40) | ATRAPPS1PR3CYP17A1HTT | |
| SCHEMBL24456033 | 0.80 | ATR (0.46) | ATRS1PR3CYP17A1SYKHTT | |
| SCHEMBL17616117 | 0.80 | KMT2A (0.52) | CYP17A1HTTHSP90AA1HSP90AB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1125817-C | Quinazoline derivatives as VEGF inhibitors | ZENECA LTD (GB) | 2003-10-29 | — | — | CN | disclosed |
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |
| CN-1211239-A | Quinazoline derivatives as VEGF inhibitors | ZENECA LTD (GB) | 1999-03-17 | — | — | CN | disclosed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |