Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1754092 | 0.82 | TAAR1 (0.50) | TAAR1KCNH2TMEM97SIGMAR1AOC3 | |
| SCHEMBL11540157 | 0.78 | TAAR1 (0.47) | TAAR1KCNH2TMEM97SIGMAR1AOC3 | |
| SCHEMBL7210260 | 0.78 | TAAR1 (0.52) | TAAR1KCNH2TMEM97SIGMAR1AOC3 | |
| SCHEMBL3934371 | 0.77 | IDO1 (0.42) | TAAR1AOC3IDO1LOXL2 | |
| SCHEMBL7212578 | 0.77 | CYP2D6 (0.45) | TAAR1AOC3MAOBLOXL2 | |
| SCHEMBL19574973 | 0.77 | TAAR1 (0.45) | TAAR1KCNH2TMEM97SIGMAR1AOC3 | |
| SCHEMBL24143907 | 0.75 | KCNH2 (0.44) | TAAR1KCNH2TMEM97SIGMAR1AOC3 | |
| SCHEMBL28100815 | 0.75 | KCNH2 (0.48) | TAAR1KCNH2TMEM97SIGMAR1AOC3 | |
| SCHEMBL19312085 | 0.75 | S1PR1 (0.50) | TAAR1KCNH2TMEM97SIGMAR1AOC3 | |
| SCHEMBL4047436 | 0.75 | TAAR1 (0.52) | TAAR1KCNH2TMEM97SIGMAR1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1314732-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1314731-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |