Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 5/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CCR5 | P51681 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7210846 | 1.00 | CCR1 (0.63) | CCR1CHRM2CCR5ALDH1A1LMNA | |
| SCHEMBL12121524 | 0.97 | CCR1 (0.60) | CCR1CHRM2CCR5ALDH1A1LMNA | |
| SCHEMBL14419988 | 0.95 | CCR1 (0.65) | CCR1CHRM2CCR5ALDH1A1LMNA | |
| SCHEMBL7205458 | 0.95 | CCR1 (0.57) | CCR1CHRM2CCR5ALDH1A1LMNA | |
| SCHEMBL7205463 | 0.95 | CCR1 (0.57) | CCR1CHRM2CCR5ALDH1A1LMNA | |
| SCHEMBL10287661 | 0.95 | CCR1 (0.57) | CCR1CHRM2CCR5ALDH1A1LMNA | |
| SCHEMBL12121529 | 0.95 | CCR1 (0.56) | CCR1CHRM2CCR5ALDH1A1LMNA | |
| SCHEMBL10287527 | 0.95 | CCR1 (0.58) | CCR1CHRM2CCR5ALDH1A1LMNA | |
| SCHEMBL13617096 | 0.94 | CCR1 (0.57) | CCR1CHRM2CCR5ALDH1A1LMNA | |
| SCHEMBL14419964 | 0.94 | CCR1 (0.57) | CCR1CHRM2CCR5ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653096-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-02-18 | — | — | US | disclosed |
| US-7541365-B2 | Chemokine receptor antagonists and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-06-02 | — | — | US | disclosed |
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |
| US-6613905-B1 | Treating or preventing a disease associated with aberrant leukocyte recruitment and/or activation | MILLENNIUM PHARMACEUTICALS, INC. | 2003-09-02 | — | — | US | disclosed |