Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tesaglitazar. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 19/20 | 0.94 |
| ▸ | PPARG known ✓ | P37231 | 14/20 | 0.94 |
| ▸ | PPARD | Q03181 | 10/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tesaglitazar SCHEMBL7211452 | 0.97 | PPARA (0.96) | PPARAPPARGPPARD | |
| SCHEMBL5368994 | 0.97 | PPARA (1.00) | PPARAPPARGPPARD | |
| Tesaglitazar SCHEMBL16594 | 0.97 | PPARA (1.00) | PPARAPPARGPPARD | |
| Tesaglitazar SCHEMBL600880 | 0.97 | PPARA (1.00) | PPARAPPARGPPARD | |
| Tesaglitazar SCHEMBL13602606 | 0.97 | PPARA (1.00) | PPARAPPARGPPARD | |
| Tesaglitazar SCHEMBL3162078 | 0.97 | PPARA (1.00) | PPARAPPARGPPARD | |
| SCHEMBL3262954 | 0.88 | PPARA (0.83) | PPARAPPARGPPARD | |
| SCHEMBL3262951 | 0.88 | PPARA (0.83) | PPARAPPARGPPARD | |
| SCHEMBL28649134 | 0.87 | PPARA (0.82) | PPARAPPARGPPARD | |
| SCHEMBL5993854 | 0.87 | PPARA (0.82) | PPARAPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1084103-B1 | NEW 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVE (I) | ASTRAZENECA AB (SE) | 2003-08-06 | — | — | EP | disclosed |