Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 14/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31061453 | 0.78 | FOLH1 (1.00) | FOLH1 | |
| SCHEMBL5053172 | 0.78 | FOLH1 (1.00) | FOLH1 | |
| SCHEMBL5060115 | 0.76 | FOLH1 (0.67) | FOLH1 | |
| SCHEMBL16266683 | 0.74 | TDP1 (0.41) | TDP1NR1H4EPHX2 | |
| SCHEMBL9246026 | 0.74 | TDP1 (0.54) | TDP1NR1H4EPHX2 | |
| SCHEMBL5057987 | 0.74 | FOLH1 (0.71) | FOLH1 | |
| SCHEMBL2058581 | 0.73 | FOLH1 (0.62) | FOLH1 | |
| SCHEMBL3567193 | 0.71 | TDP1 (0.51) | TDP1NR1H4EPHX2 | |
| SCHEMBL5057893 | 0.71 | FOLH1 (0.62) | FOLH1 | |
| SCHEMBL5057875 | 0.71 | FOLH1 (0.62) | FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1353903-A2 | THIOL-BASED NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002057222-A2 | THIOL-BASED NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 2002-07-25 | — | — | WO | disclosed |