Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 13/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL733967 | 0.88 | PIK3CG (0.76) | PIK3CGPIK3CDPIK3CBGAAPOLB | |
| SCHEMBL734037 | 0.87 | PIK3CG (0.76) | PIK3CGPIK3CDPIK3CBGAAPOLB | |
| SCHEMBL12105287 | 0.86 | PIK3CG (0.64) | PIK3CGPIK3CDPIK3CBGAAPOLB | |
| SCHEMBL733439 | 0.85 | PIK3CG (0.66) | PIK3CGPIK3CDPIK3CBGAAPOLB | |
| SCHEMBL734504 | 0.84 | PIK3CG (0.76) | PIK3CGPIK3CDPIK3CBGAAPOLB | |
| SCHEMBL733238 | 0.84 | PIK3CG (0.77) | PIK3CGPIK3CDPIK3CBGAAPOLB | |
| SCHEMBL369837 | 0.83 | PIK3CG (0.77) | PIK3CGPIK3CDPIK3CBGAAPOLB | |
| SCHEMBL733513 | 0.82 | PIK3CG (0.77) | PIK3CGPIK3CDPIK3CBGAAPOLB | |
| Quinazolinone SCHEMBL3956959 | 0.82 | PIK3CG (0.68) | PIK3CGPIK3CDPIK3CBGAAPOLB | |
| SCHEMBL735026 | 0.82 | PIK3CG (0.77) | PIK3CGPIK3CDPIK3CBGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278748-A2 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001081346-A2 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |