Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.59 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.57 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.56 |
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220616 | 0.78 | NR3C2 (0.59) | MAPK14NR3C2MAPK13MAPK12MAPK11 | |
| SCHEMBL7214775 | 0.76 | NR3C2 (0.57) | MAPK14NR3C2MAPK13MAPK12MAPK11 | |
| SCHEMBL6983426 | 0.74 | MAPK14 (0.71) | MAPK14NR3C2CSNK1DMAPK13MAPK12 | |
| SCHEMBL6983428 | 0.74 | MAPK14 (0.71) | MAPK14NR3C2CSNK1DMAPK13MAPK12 | |
| SCHEMBL27637382 | 0.73 | NR3C2 (0.61) | MAPK14NR3C2 | |
| SCHEMBL4539921 | 0.73 | NR3C2 (1.00) | NR3C2 | |
| SCHEMBL828307 | 0.72 | MAPK14 (0.80) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL27742800 | 0.72 | MAPK9 (0.51) | MAPK14NR3C2 | |
| SCHEMBL13937256 | 0.72 | MAPK14 (0.50) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL5353405 | 0.72 | MAPK14 (0.68) | MAPK14CSNK1DMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509361-B1 | Inhibit the activity of p38 MAP kinase. Also contemplated by the invention are processes for the preparation of the contemplated compounds and for the use of a contemplated compound in treating a mammalian host having a p38 kinase or | PHARMACIA CORPORATION | 2003-01-21 | — | — | US | disclosed |
| EP-1077971-A1 | 1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058523-A1 | 1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 1999-11-18 | — | — | WO | disclosed |