Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 8/20 | 0.61 |
| ▸ | KDR | P35968 | 11/20 | 0.59 |
| ▸ | FLT1 | P17948 | 5/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.57 |
| ▸ | FLT4 | P35916 | 2/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.57 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.57 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.57 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | KIF5B | P33176 | 2/20 | 0.54 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215843 | 0.89 | EGFR (0.59) | MAPK14EGFRKDRFLT1FGFR1 | |
| SCHEMBL6431781 | 0.88 | FLT1 (0.57) | MAPK14EGFRKDRFLT1FGFR1 | |
| SCHEMBL7215142 | 0.87 | KDR (0.75) | MAPK14EGFRKDRFLT1FGFR1 | |
| SCHEMBL7455732 | 0.87 | KDR (0.75) | MAPK14EGFRKDRFLT1FGFR1 | |
| Hydrochloric Acid SCHEMBL7211039 | 0.86 | KDR (0.74) | MAPK14EGFRKDRFLT1FGFR1 | |
| SCHEMBL6099840 | 0.85 | FLT1 (0.57) | MAPK14EGFRKDRFLT1FGFR1 | |
| SCHEMBL7209617 | 0.84 | EGFR (0.64) | MAPK14EGFRKDRFLT1FGFR1 | |
| SCHEMBL7211052 | 0.84 | EGFR (0.59) | MAPK14EGFRKDRFLT1FGFR1 | |
| SCHEMBL7451653 | 0.83 | EGFR (0.59) | MAPK14EGFRKDRFLT1FGFR1 | |
| Hydrochloric Acid SCHEMBL7454404 | 0.83 | EGFR (0.58) | MAPK14EGFRKDRFLT1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |