Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.82 |
| ▸ | MAPK13 | O15264 | 15/20 | 0.82 |
| ▸ | MAPK12 | P53778 | 15/20 | 0.82 |
| ▸ | MAPK11 | Q15759 | 15/20 | 0.82 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.73 |
| ▸ | RAF1 | P04049 | 3/20 | 0.60 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215450 | 1.00 | MAPK14 (0.82) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7221086 | 0.92 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7217289 | 0.92 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7217284 | 0.92 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7221081 | 0.92 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7221255 | 0.89 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7221239 | 0.89 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7221963 | 0.88 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7221960 | 0.88 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7221967 | 0.88 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602872-B1 | Substituted pyridazines having cytokine inhibitory activity | MERCK & CO., INC. | 2003-08-05 | — | — | US | disclosed |