Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.70 |
| ▸ | RAB9A | P51151 | 9/20 | 0.70 |
| ▸ | NPC1 | O15118 | 8/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | EIF4E | P06730 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | RARA | P10276 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 1/20 | 0.46 |
| ▸ | RARG | P13631 | 1/20 | 0.46 |
| ▸ | PTPRF | P10586 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12171823 | 0.87 | EIF4E (0.60) | KDM4ERAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7220948 | 0.86 | NPC1 (0.59) | KDM4ERAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7214925 | 0.82 | KDM4E (0.70) | KDM4ERAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1169786 | 0.81 | KDM4E (0.78) | KDM4ERAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7507983 | 0.81 | KDM4E (1.00) | KDM4ERAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7221293 | 0.81 | KDM4E (1.00) | KDM4ERAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14157036 | 0.79 | KDM4E (0.80) | KDM4ERAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14157037 | 0.79 | KDM4E (0.80) | KDM4ERAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7215690 | 0.79 | KDM4E (0.80) | KDM4ERAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7220939 | 0.79 | KDM4E (0.80) | KDM4ERAB9ANPC1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545009-B1 | Imidazole, oxazole and thiazole derivatives for regulation of peroxisome proliferator-activated receptor function; improving insulin resistance, treating impaired glucose tolerance and obesity, enhancing insulin sensitivity, etc. | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-04-08 | — | — | US | disclosed |