Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.89 |
| ▸ | RET | P07949 | 9/20 | 0.89 |
| ▸ | KIF5B | P33176 | 8/20 | 0.89 |
| ▸ | FLT1 | P17948 | 5/20 | 0.89 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.89 |
| ▸ | RAF1 | P04049 | 3/20 | 0.74 |
| ▸ | BRAF | P15056 | 3/20 | 0.74 |
| ▸ | EGFR | P00533 | 3/20 | 0.64 |
| ▸ | FLT4 | P35916 | 2/20 | 0.64 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.59 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.59 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5958928 | 0.94 | KDR (1.00) | KDRRETKIF5BFLT1FGFR1 | |
| Hydrochloric Acid SCHEMBL7215166 | 0.93 | KDR (0.98) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL7214452 | 0.86 | KDR (0.84) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL7211043 | 0.86 | KDR (0.84) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL7209561 | 0.86 | KDR (0.67) | KDRRETKIF5BFLT1FGFR1 | |
| Hydrochloric Acid SCHEMBL7215782 | 0.85 | KDR (0.82) | KDRRETKIF5BFLT1FGFR1 | |
| Hydrochloric Acid SCHEMBL7448336 | 0.85 | KDR (0.66) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL2055589 | 0.85 | RAF1 (0.76) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL15052297 | 0.85 | RAF1 (1.00) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL5958939 | 0.84 | KDR (1.00) | KDRRETKIF5BFLT1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |