Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 1.00 |
| ▸ | RAB9A | P51151 | 10/20 | 1.00 |
| ▸ | NPC1 | O15118 | 8/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | CRHBP | P24387 | 1/20 | 0.71 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | EIF4E | P06730 | 1/20 | 0.56 |
| ▸ | RARA | P10276 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7217213 | 1.00 | KDM4E (1.00) | KDM4ERAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL7507983 | 0.88 | KDM4E (1.00) | KDM4ERAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL7221293 | 0.88 | KDM4E (1.00) | KDM4ERAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL14157036 | 0.86 | KDM4E (0.80) | KDM4ERAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL14157037 | 0.86 | KDM4E (0.80) | KDM4ERAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL7220939 | 0.86 | KDM4E (0.80) | KDM4ERAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL7215690 | 0.86 | KDM4E (0.80) | KDM4ERAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL6197531 | 0.86 | KDM4E (0.75) | KDM4ERAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL11466217 | 0.85 | KDM4E (0.86) | KDM4ERAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL7217101 | 0.85 | KDM4E (0.78) | KDM4ERAB9ANPC1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545009-B1 | Imidazole, oxazole and thiazole derivatives for regulation of peroxisome proliferator-activated receptor function; improving insulin resistance, treating impaired glucose tolerance and obesity, enhancing insulin sensitivity, etc. | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-04-08 | — | — | US | disclosed |
| EP-1092711-A1 | RETINOID-ASSOCIATED RECEPTOR REGULATORS | Takeda Chemical Industries, Ltd. (JP) | 2001-04-18 | — | — | EP | disclosed |