Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 14/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012303 | 0.89 | SRC (0.52) | SRCEGFRKDRPDPK1 | |
| SCHEMBL1780281 | 0.89 | SRC (0.52) | SRCEGFRKDRPDPK1 | |
| SCHEMBL3065643 | 0.85 | SRC (0.43) | SRCKDRKDM4EGAAMAPK1 | |
| SCHEMBL3065645 | 0.85 | SRC (0.43) | SRCKDRKDM4EGAAMAPK1 | |
| SCHEMBL4380700 | 0.85 | SRC (0.49) | SRCEGFRKDRPDPK1 | |
| SCHEMBL263797 | 0.84 | PARP1 (0.46) | SRCEGFRKDR | |
| SCHEMBL29478509 | 0.84 | PARP1 (0.46) | SRCEGFRKDR | |
| SCHEMBL8917 | 0.83 | SRC (0.63) | SRCEGFRPDPK1KDM4EGAA | |
| SCHEMBL664912 | 0.82 | SRC (0.51) | SRCKDRKDM4EGAA | |
| SCHEMBL13299042 | 0.82 | SRC (0.51) | SRCEGFRKDRKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |