Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 14/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 4/20 | 0.57 |
| ▸ | GLA | P06280 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.57 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
| ▸ | F2 | P00734 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7623105 | 0.93 | KMT2A (0.59) | KMT2AHSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL7623795 | 0.83 | KMT2A (0.53) | KMT2AHSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL11043060 | 0.82 | KMT2A (0.68) | KMT2AHSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL7219824 | 0.78 | KMT2A (0.72) | KMT2AHSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL11474052 | 0.78 | KMT2A (0.68) | KMT2AHSD17B10ALDH1A1MAPTHPGD | |
| SCHEMBL7219896 | 0.77 | C1S (0.66) | KMT2AHSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL28063309 | 0.74 | KMT2A (0.78) | KMT2AHSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL7623913 | 0.74 | KMT2A (0.59) | KMT2AALDH1A1KDM4EMAPTGAA | |
| SCHEMBL13381577 | 0.73 | KMT2A (0.75) | KMT2AHSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL13791553 | 0.72 | KMT2A (0.85) | KMT2AHSD17B10ALDH1A1MAPTF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653340-B1 | 2-amidino-5 or 6-benzofuranyl or benzothiophenyl 2-furanyl, thiophenyl or benzyl carboxylates; serine protease inhibitors potent against Factor D of the alternate complement pathway | BIOCRYST PHARMACEUTICALS, INC. | 2003-11-25 | — | — | US | disclosed |
| EP-1066272-A4 | NOVEL COMPOUNDS USEFUL IN THE COMPLEMENT, COAGULAT AND KALLIKREIN PATHWAYS AND METHOD FOR THEIR PREPARATION | BIOCRYST PHARM INC (US) | 2002-03-13 | — | — | EP | disclosed |
| EP-1066272-A1 | NOVEL COMPOUNDS USEFUL IN THE COMPLEMENT, COAGULAT AND KALLIKREIN PATHWAYS AND METHOD FOR THEIR PREPARATION | BIOCRYST PHARMACEUTICALS INC. (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1998055471-A1 | NOVEL COMPOUNDS USEFUL IN THE COMPLEMENT, COAGULAT AND KALLIKREIN PATHWAYS AND METHOD FOR THEIR PREPARATION | BIOCRYST PHARMACEUTICALS, INC. (US) | 1998-12-10 | — | — | WO | disclosed |