Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL361682 | 0.97 | — | — | |
| SCHEMBL1194 | 0.97 | — | — | |
| SCHEMBL8373240 | 0.97 | POLB (0.50) | POLBSMN1; SMN2HSD17B10CXCR4KDM4E | |
| SCHEMBL7683711 | 0.95 | CXCR4 (0.52) | POLBSMN1; SMN2HSD17B10CXCR4KDM4E | |
| SCHEMBL29505898 | 0.95 | POLB (0.48) | POLBSMN1; SMN2HSD17B10CXCR4KDM4E | |
| Hydrochloric Acid SCHEMBL7572884 | 0.95 | SMN1; SMN2 (0.48) | POLBSMN1; SMN2HSD17B10CXCR4KDM4E | |
| SCHEMBL29707540 | 0.95 | POLB (0.48) | POLBSMN1; SMN2HSD17B10CXCR4KDM4E | |
| SCHEMBL12958863 | 0.95 | KDM4E (0.50) | POLBSMN1; SMN2HSD17B10CXCR4KDM4E | |
| SCHEMBL13014195 | 0.95 | CXCR4 (0.52) | POLBSMN1; SMN2HSD17B10CXCR4KDM4E | |
| Hydrochloric Acid SCHEMBL4078377 | 0.95 | SMN1; SMN2 (0.48) | POLBSMN1; SMN2HSD17B10CXCR4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10323043-B2 | Derivatives of macrocyclic N-aryl-tricyclopyrimidine-2-amine polyethers as inhibitors of FTL3 and JAK | PIERRE FABRE MEDICAMENT (FR) | 2019-06-18 | — | — | US | disclosed |
| CN-105037689-B | Intrinsic fire retarding epoxide resin of Halogen and preparation method thereof | 四川大学 | 2018-01-30 | — | — | CN | disclosed |
| US-20170283432-A1 | DERIVATIVES OF MACROCYCLIC N-ARYL-TRICYCLOPYRIMIDINE-2-AMINE POLYETHERS AS INHIBITORS OF FTL3 AND JAK | PIERRE FABRE MEDICAMENT (FR) | 2017-10-05 | — | — | US | disclosed |
| CN-105037689-A | Halogen-free intrinsic flame retardant epoxy resin and preparing method thereof | UNIV SICHUAN | 2015-11-11 | — | — | CN | disclosed |
| CN-102781571-B | Catalyst and method for producing an amine | BASF SE | 2015-06-17 | — | — | CN | disclosed |
| CN-102639231-B | Catalyst and method for producing an amine | BASF SE | 2014-12-10 | — | — | CN | disclosed |
| CN-103945935-A | Process for producing Sn-containing catalysts | BASF SE | 2014-07-23 | — | — | CN | disclosed |
| CN-101903095-B | Process for preparing amines | BASF SE | 2013-07-10 | — | — | CN | disclosed |
| CN-101903096-B | Method for the production of an amine | BASF SE | 2013-04-03 | — | — | CN | disclosed |
| CN-101903094-B | Process for producing amines | BASF SE | 2013-03-20 | — | — | CN | disclosed |
| CN-102781571-A | Catalyst and method for producing an amine | BASF SE | 2012-11-14 | — | — | CN | disclosed |
| CN-102639231-A | Catalyst and method for producing an amine | BASF SE | 2012-08-15 | — | — | CN | disclosed |
| CN-101903095-A | Process for preparing amines | BASF SE | 2010-12-01 | — | — | CN | disclosed |
| CN-101903096-A | Method for the production of an amine | BASF SE | 2010-12-01 | — | — | CN | disclosed |
| CN-101903093-A | Method for producing an amine | BASF SE | 2010-12-01 | — | — | CN | disclosed |
| CN-101903092-A | Method for producing an amine | BASF SE | 2010-12-01 | — | — | CN | disclosed |
| CN-101903094-A | Process for producing amines | BASF SE | 2010-12-01 | — | — | CN | disclosed |
| CN-101903097-A | Method for the production of an amine | BASF SE | 2010-12-01 | — | — | CN | disclosed |
| EP-1341412-A1 | INDOLOCARBAZOLE ANTICANCER AGENTS AND METHODS OF USING THEM | Advanced Life Sciences, Inc. (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002048166-A1 | INDOLOCARBAZOLE ANTICANCER AGENTS AND METHODS OF USING THEM | ADVANCED LIFE SCIENCES, INC. (US) | 2002-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170283432-A1 | DERIVATIVES OF MACROCYCLIC N-ARYL-TRICYCLOPYRIMIDINE-2-AMINE POLYETHERS AS INHIBITORS OF FTL3 AND JAK | JAK2, JAK3, JAK1 | POLB 2802/4885SMN1; SMN2 4368/4885HSD17B10 3710/4885 |
| US-10323043-B2 | Derivatives of macrocyclic N-aryl-tricyclopyrimidine-2-amine polyethers as inhibitors of FTL3 and JAK | JAK2, JAK3, JAK1 | POLB 2802/4885SMN1; SMN2 4368/4885HSD17B10 3710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.