Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7223193 | 0.89 | PIM1 (0.32) | PDE4BPDE4DGCKNPSR1 | |
| SCHEMBL7218337 | 0.88 | GCK (0.33) | PDE4BPDE4DGCKNPSR1 | |
| SCHEMBL7223026 | 0.88 | GCK (0.33) | PDE4BPDE4DGCKNPSR1 | |
| SCHEMBL7223477 | 0.87 | HRH4 (0.30) | — | |
| SCHEMBL7221707 | 0.87 | GCK (0.32) | GCKNPSR1 | |
| SCHEMBL7223214 | 0.86 | NPSR1 (0.34) | PDE4BPDE4DGCKNPSR1 | |
| SCHEMBL7216130 | 0.86 | GCK (0.36) | GCKNPSR1 | |
| SCHEMBL7222958 | 0.86 | NPSR1 (0.34) | PDE4BPDE4DGCKNPSR1 | |
| SCHEMBL7222537 | 0.85 | GCK (0.32) | GCKNPSR1 | |
| SCHEMBL7222707 | 0.85 | GCK (0.34) | PDE4BPDE4DGCKNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653471-B2 | Tricyclic heteroaromatic compounds containing pyrrole ring; central nervous system disorder treatment; side effect reduction | NEUROGEN CORPORATION | 2003-11-25 | — | — | US | disclosed |