SCHEMBL7217048

SCHEMBL7217048

COC(C)c1nc2c(N)nc3ccccc3c2n1CCNC(=O)O

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 0.46
TLR8 Q9NR97 4/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5355169 0.89 TLR7 (0.52) TLR7TLR8
SCHEMBL6813131 0.85 TLR8 (0.47) TLR7TLR8
SCHEMBL3972283 0.82 TLR7 (0.56) TLR7TLR8
SCHEMBL6722296 0.81 TLR7 (0.56) TLR7TLR8
SCHEMBL12231273 0.80 TLR7 (0.68) TLR7TLR8
SCHEMBL1952404 0.80 TLR7 (0.59) TLR7
SCHEMBL8861479 0.80 TLR7 (0.65) TLR7TLR8
SCHEMBL3518273 0.79 TLR7 (0.61) TLR7TLR8
SCHEMBL5357840 0.79 TLR7 (0.52) TLR7TLR8
SCHEMBL3865842 0.79 TLR7 (0.54) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6573273-B1 Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can 3M INNOVATIVE PROPERTIES COMPANY 2003-06-03 US disclosed