Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12285138 | 0.70 | KDM4E (0.55) | KDM4EHSD17B10LMNAALDH1A1HPGD | |
| SCHEMBL16416223 | 0.70 | KDM4E (0.46) | MMP12KDM4EHSD17B10LMNAALDH1A1 | |
| SCHEMBL857818 | 0.69 | KDM4E (0.48) | KDM4EHSD17B10LMNAALDH1A1HPGD | |
| SCHEMBL29532068 | 0.69 | KDM4E (0.48) | KDM4EHSD17B10LMNAALDH1A1HPGD | |
| SCHEMBL1257525 | 0.68 | KDM4E (0.50) | KDM4EHSD17B10LMNAALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL28031937 | 0.68 | BCHE (0.48) | KDM4EHSD17B10LMNAALDH1A1HPGD | |
| SCHEMBL1257333 | 0.67 | PARP1 (0.63) | MMP12KDM4EHSD17B10LMNAALDH1A1 | |
| SCHEMBL29420513 | 0.66 | SMN1; SMN2 (0.48) | KDM4EHSD17B10LMNAALDH1A1HPGD | |
| SCHEMBL830265 | 0.66 | SMN1; SMN2 (0.48) | KDM4EHSD17B10LMNAALDH1A1HPGD | |
| SCHEMBL591893 | 0.66 | MAPT (0.56) | KDM4ELMNAALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596726-B1 | Method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof inhibit the epidermal growth factor receptor and related receptors and, in particular, their tyrosine kinase enzyme | WARNER LAMBERT COMPANY | 2003-07-22 | — | — | US | disclosed |
| EP-0741711-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995019970-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1995-07-27 | — | — | WO | disclosed |