SCHEMBL7218045

SCHEMBL7218045

COC(=O)C1=Cc2cc(OCc3ccc(C)cc3)ccc2CCC1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.55
MAOA P21397 3/20 0.55
NPC1 O15118 4/20 0.51
RAB9A P51151 4/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
ALDH1A1 P00352 4/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
MAPT P10636 4/20 0.49
HPGD P15428 2/20 0.49
KDM4E B2RXH2 1/20 0.49
SMN1; SMN2 Q16637 4/20 0.48
ALOX12 P18054 1/20 0.48
TP53 P04637 2/20 0.48
RXRB P28702 4/20 0.48
RXRA P19793 3/20 0.48
RXRG P48443 3/20 0.48
GAA P10253 1/20 0.45
CCR5 P51681 2/20 0.43
HRH3 Q9Y5N1 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7222742 0.91 MAOB (0.52) MAOBMAOANPC1RAB9AL3MBTL1
SCHEMBL7216351 0.90 NPC1 (0.50) MAOBMAOANPC1RAB9AL3MBTL1
SCHEMBL7222844 0.90 MAPT (0.53) MAOBMAOANPC1RAB9AL3MBTL1
SCHEMBL7222242 0.89 MAOB (0.57) MAOBMAOANPC1RAB9AL3MBTL1
SCHEMBL7222970 0.88 MAPT (0.52) MAOBMAOANPC1RAB9AL3MBTL1
SCHEMBL7221550 0.83 NPC1 (0.45) MAOBMAOANPC1RAB9AL3MBTL1
SCHEMBL7218351 0.81 CA12 (0.52) NPC1RAB9AL3MBTL1ALDH1A1MEN1
SCHEMBL7221736 0.81 NPC1 (0.44) MAOBMAOANPC1RAB9AL3MBTL1
SCHEMBL7215867 0.80 MAOB (0.49) MAOBMAOANPC1RAB9AL3MBTL1
SCHEMBL7222036 0.79 NPC1 (0.55) MAOBMAOANPC1RAB9AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6627651-B1 Exhibiting preventive and therapeutic effects against HIV infectious diseases wherein R1 is an optionally substituted five- or six-membered ring group; X1 is a free valency or the like; W is a divalent group and inhibitors of HIV (human TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-09-30 US disclosed
EP-1182195-A1 CYCLIC COMPOUNDS AND USES THEREOF Takeda Chemical Industries, Ltd. (JP) 2002-02-27 EP disclosed