Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 1.00 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2992692 | 0.87 | EGFR (0.98) | EGFRNOX4 | |
| SCHEMBL2988586 | 0.87 | EGFR (1.00) | EGFRNOX4 | |
| SCHEMBL2990650 | 0.83 | EGFR (0.93) | EGFRNOX4 | |
| SCHEMBL2989582 | 0.82 | EGFR (0.69) | EGFRABCG2 | |
| SCHEMBL923953 | 0.80 | EGFR (0.67) | EGFRABCG2 | |
| SCHEMBL2988437 | 0.78 | EGFR (0.98) | EGFR | |
| SCHEMBL5251369 | 0.75 | EGFR (0.59) | EGFR | |
| SCHEMBL2992623 | 0.74 | EGFR (1.00) | EGFRABCG2 | |
| SCHEMBL5569425 | 0.74 | EGFR (0.72) | EGFRABCG2 | |
| SCHEMBL29116561 | 0.73 | EGFR (0.60) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596726-B1 | Method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof inhibit the epidermal growth factor receptor and related receptors and, in particular, their tyrosine kinase enzyme | WARNER LAMBERT COMPANY | 2003-07-22 | — | — | US | disclosed |
| EP-0741711-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995019970-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1995-07-27 | — | — | WO | disclosed |