Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6834410 | 0.88 | NPC1 (0.36) | LMNANPC1RAB9ACHRM2CHRM4 | |
| SCHEMBL6309664 | 0.83 | MAPT (0.34) | LMNATP53MAPTKDM4EALDH1A1 | |
| SCHEMBL6830901 | 0.82 | SMN1; SMN2 (0.37) | LMNATP53MAPTNPC1RAB9A | |
| SCHEMBL7218239 | 0.82 | GCK (0.33) | LMNANPC1RAB9ACHRM2CHRM4 | |
| SCHEMBL6305849 | 0.80 | MAPT (0.36) | LMNATP53MAPTNPC1RAB9A | |
| SCHEMBL7223491 | 0.78 | GCK (0.32) | KDM4EALDH1A1 | |
| SCHEMBL7216152 | 0.77 | PDE4B (0.42) | NPC1RAB9ACHRM2CHRM4CHRM1 | |
| SCHEMBL7216346 | 0.74 | NPC1 (0.41) | LMNANPC1RAB9ACHRM2CHRM4 | |
| SCHEMBL7221974 | 0.73 | GRM4 (0.43) | LMNANPC1RAB9ACHRM2CHRM4 | |
| SCHEMBL6834487 | 0.72 | GAA (0.43) | TP53NPC1RAB9AGRM5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653471-B2 | Tricyclic heteroaromatic compounds containing pyrrole ring; central nervous system disorder treatment; side effect reduction | NEUROGEN CORPORATION | 2003-11-25 | — | — | US | disclosed |