Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.50 |
| ▸ | PDE4A | P27815 | 8/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6655858 | 0.95 | PDE4D (0.46) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6653576 | 0.95 | PDE4D (0.46) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6656644 | 0.90 | PDE4B (0.45) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6657268 | 0.90 | PDE4D (0.49) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6843999 | 0.89 | PDE4B (0.46) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7216190 | 0.86 | PDE4D (0.47) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6657886 | 0.86 | PDE4D (0.45) | PDE4BPDE4DPDE4APDE4CMAPT | |
| SCHEMBL6843996 | 0.84 | PDE4B (0.45) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6662652 | 0.84 | PDE4B (0.45) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6841935 | 0.84 | PDE4B (0.45) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6531473-B2 | Phosphodiesterase inhibitor; antiinflammatory agents | MERCK PATENT GMBH (DE) | 2003-03-11 | — | — | US | disclosed |