⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11204915 | 1.00 | — | — | |
| SCHEMBL2889946 | 0.74 | — | — | |
| SCHEMBL2889947 | 0.74 | — | — | |
| SCHEMBL15720423 | 0.69 | — | — | |
| SCHEMBL8018506 | 0.69 | — | — | |
| SCHEMBL8603388 | 0.67 | — | — | |
| SCHEMBL22207832 | 0.66 | — | — | |
| SCHEMBL22207833 | 0.66 | — | — | |
| SCHEMBL15802630 | 0.65 | — | — | |
| SCHEMBL15791897 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015165960-A1 | N-ACYLAMIDINE COMPOUNDS | BASF SE (DE) | 2015-11-05 | — | — | WO | disclosed |
| US-6576780-B1 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors | GD SEARLE & COMPANY | 2003-06-10 | — | — | US | disclosed |
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | disclosed |
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | disclosed |
| US-5981511-A | AN ENZYME INHIBITOR FOR REDUCING NITRIC OXIDE, TREATING HYPOTENSION SUCH AS TOXIC SHOCK AND THERAPY WITH CERTAIN CYTOKINES | G.D. SEARLE & CO. (US) | 1999-11-09 | — | — | US | disclosed |
| US-5945408-A | ANTIARTTHITIC AGENTS, TREATMENT OF RHEUMATISM, ANTIINFLAMATORY AGENTS, CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS, BRAIN DISORDERS, ANTIDIABETIC AGENTS, CENTRAL NERVOUS SYSTEM DISORDERS | G.D. SEARLE & CO. (US) | 1999-08-31 | — | — | US | disclosed |
| EP-0885188-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032844-A9 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | — | 1997-12-24 | — | — | WO | disclosed |
| WO-1997032844-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-09-12 | — | — | WO | disclosed |
| US-4394386-A | Fluorinated carbamate insecticides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-07-19 | — | — | US | disclosed |
| US-4393074-A | Fluorinated carbamate insecticides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-07-12 | — | — | US | disclosed |
| US-4335140-A | Insecticidal trifluoroethanimidothioate disulfides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-06-15 | — | — | US | disclosed |
| US-4323578-A | Fluorinated carbamate insecticides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-04-06 | — | — | US | disclosed |
| EP-0026569-A1 | Fluorinated carbamates, processes for their preparation, insecticidal compositions comprising them, and controlling insects thereby | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-04-08 | — | — | EP | disclosed |