Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5374214 | 0.90 | MEN1 (0.49) | MEN1KMT2AGAAMAP2K7GRIN2B | |
| SCHEMBL5365888 | 0.86 | MEN1 (0.42) | MEN1KMT2AGAAGRIN2BMAPT | |
| SCHEMBL5365942 | 0.84 | MEN1 (0.50) | MEN1KMT2A | |
| SCHEMBL5369147 | 0.82 | MEN1 (0.49) | MEN1KMT2AGAAMAP2K7GRIN2B | |
| SCHEMBL5733851 | 0.80 | MEN1 (0.50) | MEN1KMT2AGAAMAP2K7GRIN2B | |
| SCHEMBL5375992 | 0.77 | MEN1 (0.53) | MEN1KMT2AGAAMAP2K7GRIN2B | |
| SCHEMBL5374143 | 0.77 | MEN1 (0.48) | MEN1KMT2AGAAMAP2K7GRIN2B | |
| SCHEMBL5369143 | 0.75 | MEN1 (0.51) | MEN1KMT2AMAP2K7GRIN2BMAPT | |
| SCHEMBL5367501 | 0.75 | GAA (0.52) | MEN1KMT2AGAAMAP2K7MAPT | |
| SCHEMBL5204085 | 0.75 | CYP2C9 (0.50) | MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6589954-B1 | Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful | SCIOS, INC. | 2003-07-08 | — | — | US | disclosed |