SCHEMBL7220697

SCHEMBL7220697

COc1ccc2ccc(S(=O)(=O)N[C@H]3CCN(Cc4cc5c(Cl)nccc5cc4N)C3=O)cc2c1

nearest known ligand 0.86

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 15/20 0.69
F2 P00734 6/20 0.69
PLG P00747 2/20 0.58
PROC P04070 2/20 0.58
PRSS1 P07477 2/20 0.58
PLAT P00750 1/20 0.58
KLK6 Q92876 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7531594 0.92 F10 (0.80) F10F2PLGPROCPRSS1
SCHEMBL7539547 0.92 F10 (0.65) F10F2PLGPROCPRSS1
SCHEMBL7536428 0.88 F10 (0.83) F10F2PLGPROCPRSS1
Trifluoroacetic Acid SCHEMBL7219109 0.87 F10 (0.71) F10F2PLGPROCPRSS1
Trifluoroacetic Acid SCHEMBL7444305 0.87 F10 (0.71) F10F2PLGPROCPRSS1
Hydrochloric Acid SCHEMBL7383898 0.85 F10 (0.78) F10F2PLGPROCPRSS1
SCHEMBL7536917 0.84 F10 (0.62) F10F2PLGPROCPRSS1
SCHEMBL7544799 0.84 F10 (0.62) F10F2PLGPROCPRSS1
Hydrochloric Acid SCHEMBL7544616 0.81 F10 (0.98) F10F2PLGPROCPRSS1
Hydrochloric Acid SCHEMBL7547368 0.81 F10 (0.98) F10F2PLGPROCPRSS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6602864-B1 Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2003-08-05 US disclosed
EP-0944386-B1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP disclosed
US-20020013310-A1 Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds AVENTIS PHARMACEUTICALS PRODUCTS INC. 2002-01-31 US disclosed
US-6281227-B1 INHIBITORS OF THE ACTIVITY OF FACTOR XA. AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2001-08-28 US disclosed
WO-2001039759-A2 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2001-06-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020013310-A1 Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds STS, ARSA, F12 F10 20/4885F2 11/4885PLG 137/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.