Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.91 |
| ▸ | ERBB2 | P04626 | 17/20 | 0.91 |
| ▸ | ERBB4 | Q15303 | 15/20 | 0.91 |
| ▸ | JAK3 | P52333 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7214306 | 0.98 | EGFR (0.90) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL7220144 | 0.95 | EGFR (1.00) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL7214608 | 0.91 | EGFR (0.91) | EGFRERBB2ERBB4 | |
| SCHEMBL7221038 | 0.89 | EGFR (0.90) | EGFRERBB2ERBB4 | |
| SCHEMBL7216617 | 0.86 | EGFR (1.00) | EGFRERBB2ERBB4 | |
| SCHEMBL7214037 | 0.85 | EGFR (0.72) | EGFRERBB2ERBB4 | |
| SCHEMBL7233594 | 0.83 | EGFR (0.67) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL7240514 | 0.83 | EGFR (0.67) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL7220753 | 0.83 | EGFR (0.84) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL7214038 | 0.83 | EGFR (0.71) | EGFRERBB2ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | claimed |
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | disclosed |