Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29921371 | 0.78 | MAPK14 (0.43) | HTR1AADRA1DADRA1AADRA1BNPC1 | |
| SCHEMBL23835283 | 0.78 | MAPK14 (0.43) | HTR1AADRA1DADRA1AADRA1BNPC1 | |
| SCHEMBL694179 | 0.77 | MAPT (0.51) | HTR1AADRA1DADRA1AADRA1BNPC1 | |
| SCHEMBL18191240 | 0.74 | ALOX5AP (0.46) | HTR1AADRA1DADRA1AADRA1BSMN1; SMN2 | |
| SCHEMBL10849569 | 0.73 | MRGPRX4 (0.49) | HTR1AADRA1DADRA1AADRA1BNPC1 | |
| SCHEMBL3240051 | 0.71 | NPC1 (0.55) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL20482580 | 0.71 | MGAM (0.49) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL17260906 | 0.70 | FEN1 (0.41) | HTR1AADRA1DADRA1AADRA1BSMN1; SMN2 | |
| SCHEMBL210025 | 0.69 | MAOB (0.49) | NPC1RAB9ASMN1; SMN2MAPTL3MBTL1 | |
| Benzyl Bromide SCHEMBL17260893 | 0.69 | FEN1 (0.39) | HTR1AADRA1DADRA1AADRA1BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421835-A1 | N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INHIBITORS | Glaxo Group Limited (GB) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122089-A1 | N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INHIBITORS | GLAXO GROUP LIMITED (GB) | 2010-10-28 | — | — | WO | disclosed |