Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.77 |
| ▸ | ACE | P12821 | 3/20 | 0.77 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.41 |
| ▸ | FNTA | P49354 | 7/20 | 0.37 |
| ▸ | FNTB | P49356 | 7/20 | 0.37 |
| ▸ | GRN | P28799 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869936 | 0.87 | ACE2 (0.59) | ACE2ACECYP11B1CYP11B2FNTA | |
| Ore-1001 SCHEMBL5869293 | 0.87 | ACE2 (1.00) | ACE2ACECYP11B1CYP11B2FNTA | |
| Ore-1001 SCHEMBL9994114 | 0.87 | ACE2 (1.00) | ACE2ACECYP11B1CYP11B2FNTA | |
| Ore-1001 SCHEMBL9992978 | 0.87 | ACE2 (1.00) | ACE2ACECYP11B1CYP11B2FNTA | |
| Ore-1001 SCHEMBL1656029 | 0.87 | ACE2 (1.00) | ACE2ACECYP11B1CYP11B2FNTA | |
| Ore-1001 SCHEMBL2223815 | 0.87 | ACE2 (1.00) | ACE2ACECYP11B1CYP11B2FNTA | |
| Ore-1001 SCHEMBL5869286 | 0.87 | ACE2 (1.00) | ACE2ACECYP11B1CYP11B2FNTA | |
| Ore-1001 SCHEMBL1691048 | 0.87 | ACE2 (1.00) | ACE2ACECYP11B1CYP11B2FNTA | |
| Ore-1001 SCHEMBL1691045 | 0.87 | ACE2 (1.00) | ACE2ACECYP11B1CYP11B2FNTA | |
| Ore-1001 SCHEMBL9993284 | 0.87 | ACE2 (1.00) | ACE2ACECYP11B1CYP11B2FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |