Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7229667 | 0.83 | GAA (0.32) | ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL7230897 | 0.83 | CHRM5 (0.37) | — | |
| SCHEMBL7224033 | 0.80 | KDM4E (0.39) | KDM4EHSD17B10TSHRALOX15ALDH1A1 | |
| SCHEMBL7228350 | 0.78 | KDM4E (0.50) | KDM4EHSD17B10TSHRALOX15ALDH1A1 | |
| SCHEMBL7220740 | 0.76 | KDM4E (0.41) | KDM4EHSD17B10TSHRALOX15ALDH1A1 | |
| SCHEMBL7220747 | 0.76 | KDM4E (0.41) | KDM4EHSD17B10TSHRALOX15ALDH1A1 | |
| SCHEMBL7221972 | 0.74 | — | — | |
| SCHEMBL7704837 | 0.73 | KDM4E (0.45) | KDM4EHSD17B10TSHRALOX15ALDH1A1 | |
| SCHEMBL7227987 | 0.73 | KDM4E (0.45) | KDM4EHSD17B10TSHRALOX15ALDH1A1 | |
| SCHEMBL7227990 | 0.73 | KDM4E (0.45) | KDM4EHSD17B10TSHRALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552226-B1 | Rapid; low temperature; one pot synthesis; reduced catalytic quantities of such as lewis acid and tertiary amine; entiomerically pure products | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-04-22 | — | — | US | disclosed |
| WO-2002026683-A1 | TANDEM ACYL-CLAISEN REARRANGEMENT IN THE PREPARATION OF CHIRAL PRODUCTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-04-04 | — | — | WO | disclosed |