Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KCNJ5 | P48544 | 5/20 | 0.41 |
| ▸ | KCNJ3 | P48549 | 5/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084597 | 0.84 | KCNJ5 (0.55) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL7086210 | 0.83 | KMT2A (0.42) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL7085104 | 0.81 | KMT2A (0.51) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL7085428 | 0.81 | KCNJ5 (0.55) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL7091440 | 0.79 | GAA (0.53) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL7088706 | 0.79 | MEN1 (0.60) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL7088770 | 0.78 | MEN1 (0.55) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL7088364 | 0.76 | MEN1 (0.58) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL7085782 | 0.76 | MEN1 (0.47) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL7088341 | 0.76 | MEN1 (0.52) | MEN1KMT2AALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559185-B2 | Nitromethyl ketone compounds having aldose reduction inhibiting properties and methods for their use | MERCK PATENT GMBH (DE) | 2003-05-06 | — | — | US | disclosed |