Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | DDO | Q99489 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27697868 | 0.85 | HCAR2 (0.53) | HCAR2POLBALDH1A1KDM4EMEN1 | |
| SCHEMBL30777432 | 0.82 | HCAR2 (0.59) | HCAR2POLBALDH1A1KDM4EMEN1 | |
| SCHEMBL7817677 | 0.82 | HCAR2 (0.59) | HCAR2POLBALDH1A1KDM4EMEN1 | |
| SCHEMBL7674347 | 0.82 | HCAR2 (0.53) | HCAR2POLBALDH1A1KDM4EMEN1 | |
| SCHEMBL846393 | 0.80 | CYP2C9 (0.61) | HCAR2POLBALDH1A1KDM4EMEN1 | |
| SCHEMBL7471695 | 0.80 | HCAR2 (0.57) | HCAR2POLBALDH1A1KDM4EMEN1 | |
| SCHEMBL1244630 | 0.80 | KDM4E (0.57) | HCAR2POLBALDH1A1KDM4EMEN1 | |
| SCHEMBL30281282 | 0.80 | CYP2C9 (0.61) | HCAR2POLBALDH1A1KDM4EMEN1 | |
| SCHEMBL3938261 | 0.78 | ATM (0.59) | ALDH1A1KDM4ECYP2C9CYP2C19HTT | |
| SCHEMBL51830 | 0.78 | HCAR2 (0.70) | HCAR2POLBALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111116579-B | Synthesis method of nicergoline | 江苏汉斯通药业有限公司 | 2021-04-27 | — | — | CN | claimed |
| CN-111116579-A | Synthesis method of nicergoline | 江苏汉斯通药业有限公司 | 2020-05-08 | — | — | CN | claimed |
| EP-4486453-A1 | BENZAMIDE COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS | F. Hoffmann-La Roche AG (CH) | 2025-01-08 | — | — | EP | disclosed |
| CN-118843616-A | Benzamide compounds for the treatment of bacterial infections | 豪夫迈·罗氏有限公司 | 2024-10-25 | — | — | CN | disclosed |
| WO-2024124287-A1 | COMPOUNDS FOR TREATING VIRAL INFECTION | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2024-06-20 | — | — | WO | disclosed |
| WO-2023166103-A1 | BENZAMIDE COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-09-07 | — | — | WO | disclosed |
| CN-113480532-B | Synthesis method of nicergoline | 福安药业集团重庆博圣制药有限公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-113480532-A | Synthesis method of nicergoline | 福安药业集团重庆博圣制药有限公司 | 2021-10-08 | — | — | CN | disclosed |
| CN-111116579-B | Synthesis method of nicergoline | 江苏汉斯通药业有限公司 | 2021-04-27 | — | — | CN | disclosed |
| EP-3768264-A1 | AROMATIC ALDEHYDES WITH SUSTAINED AND ENHANCED IN VITRO AND IN VIVO PHARMACOLOGIC ACTIVITY TO TREAT SICKLE CELL DISEASE | Virginia Commonwealth University (US) | 2021-01-27 | — | — | EP | disclosed |
| CN-111116579-A | Synthesis method of nicergoline | 江苏汉斯通药业有限公司 | 2020-05-08 | — | — | CN | disclosed |
| WO-2019182938-A1 | AROMATIC ALDEHYDES WITH SUSTAINED AND ENHANCED IN VITRO AND IN VIVO PHARMACOLOGIC ACTIVITY TO TREAT SICKLE CELL DISEASE | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2019-09-26 | — | — | WO | disclosed |
| CN-101610761-A | 1-amino methyl-L-phenyl-cyclohexane-derivant as the DDP-IV inhibitor | NOVARTIS AG (CH) | 2009-12-23 | — | — | CN | disclosed |
| CN-101102796-A | Benzothiazole formulations and uses thereof | ARES TRADING SA (CH) | 2008-01-09 | — | — | CN | disclosed |
| CN-101061105-A | Potentiators of glutamate receptors | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |
| US-6624188-B1 | Administered to treat or prevent one or more of the diseases and conditions selected from the group consisting of dermatoses, atherosclerosis and restenosis resulting from neointimal hyperproliferation, non-malignant and | ALLERGAN, INC. | 2003-09-23 | — | — | US | disclosed |
| US-5324840-A | Skin disorders | ALLERGAN, INC. (US) | 1994-06-28 | — | — | US | disclosed |