⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17818252 | 0.96 | — | — | |
| SCHEMBL3346553 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL17080481 | 0.65 | — | — | |
| SCHEMBL7227907 | 0.60 | — | — | |
| SCHEMBL7934238 | 0.58 | — | — | |
| SCHEMBL4847 | 0.56 | — | — | |
| SCHEMBL26494 | 0.56 | — | — | |
| SCHEMBL17771 | 0.55 | — | — | |
| SCHEMBL16654194 | 0.55 | — | — | |
| SCHEMBL6812435 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10000512-B2 | Compounds for the treatment of infectious diseases | HOFFMANN-LA ROCHE INC. (US) | 2018-06-19 | — | — | US | disclosed |
| EP-3204392-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF INFECTIOUS DISEASES | F. Hoffmann-La Roche AG (CH) | 2017-08-16 | — | — | EP | disclosed |
| US-20170217990-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 2017-08-03 | — | — | US | disclosed |
| WO-2016055553-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF INFECTIOUS DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2016-04-14 | — | — | WO | disclosed |
| US-6525074-B2 | Peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras | MERCK & CO., INC. | 2003-02-25 | — | — | US | disclosed |
| US-20020049217-A1 | Inhibitors of prenyl-protein transferase | MERCK SHARP & DOHME CORP. | 2002-04-25 | — | — | US | disclosed |