Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8850625 | 0.83 | CYP4F2 (0.62) | LTA4HSMN1; SMN2CYP4F2CYP4A11KDM4E | |
| SCHEMBL5725928 | 0.81 | SMN1; SMN2 (0.65) | HDAC1SLC7A5SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5726219 | 0.80 | SLC7A5 (0.49) | HDAC1SLC7A5SMN1; SMN2KDM4EMITF | |
| SCHEMBL10243056 | 0.80 | DRD4 (0.60) | HDAC1LTA4HSLC7A5KDM4EMITF | |
| SCHEMBL12028729 | 0.79 | SLC7A5 (0.56) | SLC7A5SMN1; SMN2CYP4F2CYP4A11KDM4E | |
| SCHEMBL5046368 | 0.79 | TLR7 (0.53) | HDAC1SLC7A5SMN1; SMN2CYP4F2CYP4A11 | |
| SCHEMBL5725017 | 0.78 | HDAC1 (0.46) | HDAC1SLC7A5SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL5725135 | 0.78 | TLR7 (0.54) | SLC7A5CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL9084330 | 0.77 | CYP4F2 (0.54) | LTA4HSMN1; SMN2CYP4F2CYP4A11KDM4E | |
| SCHEMBL1628160 | 0.76 | CYP4A11 (0.57) | HDAC1SLC7A5CYP4F2CYP4A11KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649657-B2 | Administering amide to treat osteoporosis | PFIZER INC. | 2003-11-18 | — | — | US | disclosed |
| US-6344485-B1 | Method for treating glaucoma | PFIZER INC. | 2002-02-05 | — | — | US | disclosed |