Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.58 |
| ▸ | CDK7 | P50613 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13524909 | 0.89 | KDR (0.80) | KDRCHEK1MEN1NPC1CASP3 | |
| SCHEMBL14240414 | 0.86 | KDR (0.76) | KDRCHEK1ABL1LCKCSF1R | |
| SCHEMBL6180047 | 0.84 | KDR (0.77) | KDRABL1LCKCSF1RPDGFRB | |
| SCHEMBL7237187 | 0.82 | KDR (0.73) | KDRCHEK1ABL1LCKCSF1R | |
| SCHEMBL6179920 | 0.81 | KDR (1.00) | KDRABL1LCKCSF1RPDGFRB | |
| SCHEMBL7242068 | 0.80 | KDR (0.68) | KDRCHEK1ABL1LCKCSF1R | |
| SCHEMBL7227864 | 0.80 | KDR (1.00) | KDRABL1LCKCSF1RPDGFRB | |
| SCHEMBL7234816 | 0.80 | KDR (0.66) | KDRCHEK1ABL1LCKCSF1R | |
| SCHEMBL6179560 | 0.79 | KDR (0.78) | KDRLCKMEN1NPC1RAB9A | |
| SCHEMBL6328806 | 0.78 | KDR (0.71) | KDRABL1LCKCSF1RPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586424-B2 | Anticancer agents; anticholesterol agents | MERCK & CO., INC. | 2003-07-01 | — | — | US | disclosed |
| US-6586423-B2 | 2-(Pyridin-2-ylamino)-thiazole-5-carbonitrile derivatives; angiogenesis inhibitors; antitumor and anticarcinogenic agents; atherosclerosis, macular degeneration, diabetic retinopathy | MERCK & CO., INC. | 2003-07-01 | — | — | US | disclosed |