Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 10/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 8/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 8/20 | 0.45 |
| ▸ | F10 | P00742 | 6/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7229075 | 0.93 | GRM2 (0.47) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7237481 | 0.90 | GRM2 (0.52) | GRM2 | |
| SCHEMBL8549450 | 0.90 | GRM2 (0.52) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7236579 | 0.90 | GRM2 (0.47) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL8547898 | 0.89 | GRM2 (0.53) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL8543589 | 0.86 | GRM2 (0.52) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL8549715 | 0.85 | GRM2 (0.48) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL8545210 | 0.85 | GRM2 (0.55) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL8548582 | 0.85 | GRM2 (0.50) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7238821 | 0.83 | GRM2 (0.45) | GRM2ITGB3PRSS1PRSS2ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602876-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2003-08-05 | — | — | US | disclosed |
| US-6204280-B1 | OXAZOLIDINONE DERIVATIVE, ANTICOAGULANT | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 2001-03-20 | — | — | US | disclosed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |