Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | VCP | P55072 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4447863 | 0.88 | CYP19A1 (0.68) | KDM4ECYP19A1CYP3A4ATMRAB9A | |
| SCHEMBL2094645 | 0.80 | KDM4E (0.59) | KDM4ECYP19A1CYP3A4ATMRAB9A | |
| SCHEMBL2094647 | 0.80 | KDM4E (0.59) | KDM4ECYP19A1CYP3A4ATMRAB9A | |
| SCHEMBL11492405 | 0.79 | KDM4E (0.54) | KDM4ECYP19A1CYP3A4ATMRAB9A | |
| SCHEMBL11492404 | 0.79 | KDM4E (0.54) | KDM4ECYP19A1CYP3A4ATMRAB9A | |
| SCHEMBL11486121 | 0.77 | KDM4E (0.60) | KDM4ECYP19A1CYP3A4ATMRAB9A | |
| SCHEMBL11486125 | 0.77 | KDM4E (0.60) | KDM4ECYP19A1CYP3A4ATMRAB9A | |
| SCHEMBL30837170 | 0.77 | KDM4E (0.60) | KDM4ECYP19A1CYP3A4ATMRAB9A | |
| SCHEMBL11488915 | 0.76 | KDM4E (0.54) | KDM4ECYP19A1CYP3A4ATMRAB9A | |
| SCHEMBL13978818 | 0.76 | KDM4E (0.54) | KDM4ECYP19A1CYP3A4ATMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509344-B1 | A method for treating a patient having cancer, said method comprising the step of administering to the patient an effective amount of a compound according to claim 1, whereupon said patient is treated for cancer, and wherein the cancer is | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2003-01-21 | — | — | US | disclosed |