Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18356535 | 0.81 | SCN5A (0.50) | TRPV1SCN5ASCN9AKCNA5KCNH2 | |
| SCHEMBL5918308 | 0.81 | TRPV1 (0.47) | TRPV1SCN5ASCN9A | |
| SCHEMBL11272722 | 0.79 | CETP (0.54) | TRPV1SCN5ASCN9A | |
| SCHEMBL20983702 | 0.79 | TRPV1 (0.60) | TRPV1SCN5ASCN9A | |
| SCHEMBL2716198 | 0.78 | MAP4K4 (0.54) | MAP4K4SCN5ASCN9AMEN1PSIP1 | |
| SCHEMBL30430026 | 0.78 | MAP4K4 (0.54) | MAP4K4SCN5ASCN9AMEN1PSIP1 | |
| SCHEMBL27339880 | 0.78 | MAP4K4 (0.58) | MAP4K4MEN1PSIP1AXLMKNK1 | |
| SCHEMBL5189333 | 0.77 | SCN5A (0.48) | TRPV1SCN5ASCN9A | |
| SCHEMBL15624412 | 0.76 | TRPV1 (0.47) | TRPV1 | |
| SCHEMBL7088823 | 0.76 | TSHR (0.44) | MAP4K4TRPV1SCN5ASCN9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1953979-A | Substituted 5, 12-diaza-benzoanthracene analogues | NEUROGEN CORP (US) | 2007-04-25 | — | — | CN | disclosed |
| US-6521643-B1 | Prevention and/or treatment of nitric oxide synthasey medi-ated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, diabetes, ulcerative colitis, cerebral infarction, osteoarthritis | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-02-18 | — | — | US | disclosed |
| EP-1157022-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000049015-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-24 | — | — | WO | disclosed |