Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.73 |
| ▸ | CDK4 | P11802 | 6/20 | 0.73 |
| ▸ | IGF1R | P08069 | 5/20 | 0.67 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5581900 | 0.84 | CDK4 (1.00) | CDK2CDK4IGF1RGSK3B | |
| SCHEMBL29644990 | 0.84 | CDK4 (1.00) | CDK2CDK4IGF1RGSK3B | |
| SCHEMBL29644986 | 0.84 | CDK4 (1.00) | CDK2CDK4IGF1RGSK3B | |
| SCHEMBL11339596 | 0.81 | IGF1R (1.00) | CDK2CDK4IGF1RGSK3BCDK1 | |
| SCHEMBL6644486 | 0.77 | CDK4 (0.86) | CDK2CDK4IGF1RKDRALK | |
| SCHEMBL4459525 | 0.76 | IGF1R (1.00) | CDK2CDK4IGF1RGSK3BCDK1 | |
| SCHEMBL6642542 | 0.76 | CDK4 (0.83) | CDK2CDK4IGF1RKDRALK | |
| SCHEMBL7242055 | 0.75 | CDK4 (0.81) | CDK2CDK4IGF1RCDK1KDR | |
| SCHEMBL6641459 | 0.75 | CDK2 (0.79) | CDK2CDK4IGF1RGSK3BCDK1 | |
| SCHEMBL5581580 | 0.75 | CDK4 (0.81) | CDK2CDK4IGF1RKDRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6593326-B1 | Useful as anti-cancer agents; and processes for their manufacture and pharmaceutical compositions containing them are described. Apoptotic effect in a warm-blooded animal such as man. | ASTRAZENECA AB (SE) | 2003-07-15 | — | — | US | disclosed |