Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.46 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232828 | 0.88 | MAPT (0.55) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL7234678 | 0.87 | MAPT (0.54) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL1786153 | 0.87 | MAPT (0.54) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL15797078 | 0.85 | MAPT (0.72) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL30208188 | 0.85 | MAPT (0.72) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL7235368 | 0.83 | MAPT (0.63) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL10063610 | 0.83 | MAPT (0.59) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL24511558 | 0.81 | MAPT (0.56) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL7242118 | 0.81 | MAPT (0.56) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL21533625 | 0.81 | MAPT (0.63) | MAPTALDH1A1LMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6555541-B1 | P2X7 receptor antagonists for treatment of inflammatory respiratory system disorders such as asthma; for example, 2-(3,4-Difluorophenylamino)-N-(2-methyl-5-piperazin-1-yl-methyl-phenyl) -acetamide, trihydrochloride | ASTRAZENECA UK LIMITED (GB) | 2003-04-29 | — | — | US | disclosed |