Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.62 |
| ▸ | FYN | P06241 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 3/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | VCP | P55072 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235777 | 1.00 | EGFR (0.62) | EGFRERBB2FYNSRCPIK3CD | |
| SCHEMBL7242132 | 0.90 | EGFR (0.65) | EGFRERBB2FYNSRCVCP | |
| SCHEMBL7242133 | 0.90 | EGFR (0.65) | EGFRERBB2FYNSRCVCP | |
| SCHEMBL7236338 | 0.78 | EGFR (0.67) | EGFRERBB2FYNSRCPIK3CD | |
| SCHEMBL7243002 | 0.78 | EGFR (0.78) | EGFRERBB2FYNSRCPIK3CD | |
| SCHEMBL7236332 | 0.78 | EGFR (0.67) | EGFRERBB2FYNSRCPIK3CD | |
| SCHEMBL7243000 | 0.78 | EGFR (0.78) | EGFRERBB2FYNSRCPIK3CD | |
| SCHEMBL2988661 | 0.77 | EGFR (1.00) | EGFRERBB2FYNSRC | |
| SCHEMBL2988658 | 0.77 | EGFR (1.00) | EGFRERBB2FYNSRC | |
| SCHEMBL7241888 | 0.77 | EGFR (0.65) | EGFRERBB2FYNSRCVCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | claimed |
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | disclosed |
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | disclosed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |