Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7236610 | 1.00 | POLB (0.48) | POLBKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL6163609 | 0.91 | HCRTR1 (0.51) | POLBKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL6165786 | 0.91 | HCRTR1 (0.51) | POLBKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL6165793 | 0.91 | HCRTR1 (0.51) | POLBKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL6165649 | 0.90 | TRPV1 (0.44) | POLBKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL6166196 | 0.90 | TRPV1 (0.44) | POLBKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL6167460 | 0.90 | TRPV1 (0.44) | POLBKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL6164237 | 0.90 | MEN1 (0.49) | POLBKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL6163315 | 0.90 | MEN1 (0.49) | POLBKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL6165671 | 0.90 | MEN1 (0.49) | POLBKMT2AMEN1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559163-B2 | Agonists, antagonists or inverse agonists for GABAA brain receptors; useful in diagnosis and treatment of anxiety, depression | NEUROGEN CORPORATION | 2003-05-06 | — | — | US | disclosed |