Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7229621 | 0.94 | MAPK1 (0.38) | MAPK1L3MBTL1GRM2 | |
| SCHEMBL7235819 | 0.94 | GRM2 (0.34) | MAPK1L3MBTL1GRM2 | |
| SCHEMBL8545035 | 0.88 | MAPK1 (0.38) | MAPK1L3MBTL1GRM2 | |
| SCHEMBL7237723 | 0.87 | GRM2 (0.36) | MAPK1L3MBTL1GRM2 | |
| SCHEMBL7229320 | 0.87 | MAPK1 (0.35) | MAPK1L3MBTL1GRM2 | |
| SCHEMBL8546462 | 0.84 | MAPK1 (0.40) | MAPK1L3MBTL1GRM2 | |
| SCHEMBL7228013 | 0.84 | MAPK1 (0.38) | MAPK1L3MBTL1GRM2 | |
| SCHEMBL7237901 | 0.83 | MAPK1 (0.33) | MAPK1L3MBTL1GRM2 | |
| SCHEMBL8545369 | 0.82 | MAPK1 (0.35) | MAPK1L3MBTL1GRM2 | |
| SCHEMBL7237705 | 0.81 | MAPK1 (0.36) | MAPK1L3MBTL1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602876-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2003-08-05 | — | — | US | disclosed |
| US-6204280-B1 | OXAZOLIDINONE DERIVATIVE, ANTICOAGULANT | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 2001-03-20 | — | — | US | disclosed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |