Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 15/20 | 0.78 |
| ▸ | EGFR | P00533 | 14/20 | 0.78 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.60 |
| ▸ | JAK3 | P52333 | 2/20 | 0.60 |
| ▸ | FYN | P06241 | 3/20 | 0.58 |
| ▸ | SRC | P12931 | 3/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.57 |
| ▸ | ROS1 | P08922 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.57 |
| ▸ | VCP | P55072 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233054 | 0.90 | ERBB2 (0.64) | ERBB2EGFRERBB4JAK3CHEK2 | |
| SCHEMBL7239555 | 0.90 | EGFR (0.64) | ERBB2EGFRERBB4JAK3CHEK2 | |
| SCHEMBL7236852 | 0.90 | EGFR (0.66) | ERBB2EGFRERBB4JAK3CHEK2 | |
| SCHEMBL7240419 | 0.90 | EGFR (0.64) | ERBB2EGFRERBB4JAK3CHEK2 | |
| SCHEMBL7233840 | 0.89 | EGFR (0.62) | ERBB2EGFRERBB4JAK3CHEK2 | |
| SCHEMBL7241722 | 0.89 | EGFR (0.76) | ERBB2EGFRERBB4JAK3FYN | |
| SCHEMBL7237255 | 0.88 | EGFR (0.64) | ERBB2EGFRERBB4JAK3CHEK2 | |
| SCHEMBL7234888 | 0.88 | EGFR (1.00) | ERBB2EGFRERBB4JAK3FYN | |
| SCHEMBL7243934 | 0.86 | EGFR (0.85) | ERBB2EGFRERBB4FYNSRC | |
| SCHEMBL7233918 | 0.85 | EGFR (0.70) | ERBB2EGFRERBB4JAK3CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | claimed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | disclosed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |