Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 8/20 | 0.51 |
| ▸ | PPARA | Q07869 | 4/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 4/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6074743 | 0.94 | ADRB3 (0.53) | FFAR1ADRB3LMNAPPARGADRB2 | |
| SCHEMBL6982353 | 0.94 | ADRB3 (0.53) | FFAR1ADRB3LMNAPPARGADRB2 | |
| SCHEMBL6074251 | 0.92 | ADRB3 (0.49) | FFAR1PPARAADRB3PPARGADRB2 | |
| SCHEMBL6073771 | 0.85 | PPARG (0.47) | ADRB3LMNAPPARGADRB2ADRB1 | |
| SCHEMBL7247494 | 0.85 | PPARG (0.47) | ADRB3LMNAPPARGADRB2ADRB1 | |
| SCHEMBL6075116 | 0.85 | ADRB3 (0.46) | ADRB3LMNAPPARGADRB2ADRB1 | |
| SCHEMBL6074504 | 0.83 | ADRB3 (0.49) | ADRB3ADRB2ADRB1 | |
| SCHEMBL6074499 | 0.83 | ADRB3 (0.49) | ADRB3ADRB2ADRB1 | |
| SCHEMBL6075000 | 0.81 | ADRB3 (0.60) | ADRB3ADRB2ADRB1 | |
| SCHEMBL6074996 | 0.81 | ADRB3 (0.60) | ADRB3ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525202-B2 | E.g., substituted (4-amino-5-hydroxyphenyl)-oxy-)piperidinyl thiazolidin-2,4-dione; antidiabetic agents; atherosclerosis, gastrointestinal, metabolic disorders, glaucoma, neurogenetic inflammation, ocular hypertension and frequent urination | WYETH | 2003-02-25 | — | — | US | disclosed |