Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NQO2 | P16083 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6475666 | 0.90 | MAPK14 (0.68) | MAPK14ALDH1A1LMNAPOLBNPC1 | |
| SCHEMBL6777518 | 0.86 | POLB (0.74) | MAPK14ALDH1A1LMNAPOLBNPC1 | |
| SCHEMBL6787334 | 0.83 | MAPK14 (0.74) | MAPK14ALDH1A1LMNAPOLBNPC1 | |
| SCHEMBL6781371 | 0.83 | MAPK14 (0.76) | MAPK14ALDH1A1POLBNPC1RAB9A | |
| SCHEMBL6487458 | 0.82 | MAPK14 (0.75) | MAPK14ALDH1A1POLBNPC1RAB9A | |
| SCHEMBL6532402 | 0.82 | MAPK14 (0.67) | MAPK14ALDH1A1TP53MAPTTDP1 | |
| SCHEMBL6478248 | 0.81 | MAPK14 (0.74) | MAPK14ALDH1A1LMNAPOLBNPC1 | |
| SCHEMBL6477111 | 0.81 | MAPK14 (0.70) | MAPK14ALDH1A1POLBNPC1RAB9A | |
| SCHEMBL6782336 | 0.80 | MAPK14 (1.00) | MAPK14ALDH1A1POLBNPC1RAB9A | |
| SCHEMBL6781511 | 0.80 | MAPK14 (1.00) | MAPK14ALDH1A1POLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6579872-B1 | Such as TNF, in particular of TNF alpha, and various interleukins, in particular IL-1; N-(5-(4-(3-hydroxypropoxy)benzamido)-2-methylphenyl)-3,4-dimethoxybenzamide | ASTRAZENECA AB (SE) | 2003-06-17 | — | — | US | disclosed |
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |