Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.80 |
| ▸ | TP53 | P04637 | 2/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.76 |
| ▸ | NPC1 | O15118 | 1/20 | 0.76 |
| ▸ | RAB9A | P51151 | 1/20 | 0.76 |
| ▸ | CSF1R | P07333 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782336 | 0.89 | MAPK14 (1.00) | MAPK14TP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6781511 | 0.89 | MAPK14 (1.00) | MAPK14TP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6532398 | 0.87 | MAPK14 (0.72) | MAPK14TP53SMN1; SMN2RAB9ACSF1R | |
| SCHEMBL6475666 | 0.83 | MAPK14 (0.68) | MAPK14TP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6781371 | 0.82 | MAPK14 (0.76) | MAPK14TP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2980389 | 0.82 | MAPK14 (0.86) | MAPK14TP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6487458 | 0.81 | MAPK14 (0.75) | MAPK14TP53NPC1RAB9AMAPT | |
| SCHEMBL6477643 | 0.81 | MAPK14 (0.85) | MAPK14TP53CSF1RMAPTCYP1A2 | |
| SCHEMBL6477379 | 0.81 | MAPK14 (0.85) | MAPK14TP53CSF1RMAPTCYP1A2 | |
| SCHEMBL6787334 | 0.81 | MAPK14 (0.74) | MAPK14TP53NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6579872-B1 | Such as TNF, in particular of TNF alpha, and various interleukins, in particular IL-1; N-(5-(4-(3-hydroxypropoxy)benzamido)-2-methylphenyl)-3,4-dimethoxybenzamide | ASTRAZENECA AB (SE) | 2003-06-17 | — | — | US | disclosed |
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |