Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.72 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.62 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.62 |
| ▸ | ROS1 | P08922 | 1/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.62 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235763 | 0.89 | EGFR (0.73) | EGFRERBB2ERBB4CHEK2ROS1 | |
| SCHEMBL8807778 | 0.88 | EGFR (0.77) | EGFRERBB2ERBB4ABCG2CHEK2 | |
| SCHEMBL7243449 | 0.88 | EGFR (0.70) | EGFRERBB2ERBB4ABCG2PIK3CD | |
| SCHEMBL7234328 | 0.88 | ERBB2 (0.61) | EGFRERBB2ERBB4ABCG2CHEK2 | |
| SCHEMBL8815115 | 0.86 | EGFR (0.77) | EGFRERBB2ERBB4CHEK2ROS1 | |
| SCHEMBL7236418 | 0.85 | EGFR (0.81) | EGFRERBB2ERBB4CHEK2ROS1 | |
| SCHEMBL7236415 | 0.85 | EGFR (0.81) | EGFRERBB2ERBB4CHEK2ROS1 | |
| SCHEMBL7234888 | 0.83 | EGFR (1.00) | EGFRERBB2ERBB4CHEK2ROS1 | |
| SCHEMBL24167596 | 0.83 | EGFR (0.56) | EGFRERBB2ERBB4ABCG2PIK3CD | |
| SCHEMBL7127934 | 0.83 | EGFR (0.70) | EGFRERBB2ERBB4CHEK2ROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | claimed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | disclosed |
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | disclosed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |