Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | USP8 | P40818 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 10/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 10/20 | 0.44 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL723000 | 0.86 | ACVR1 (0.47) | USP8TGFBR1ACVR1CCNT1CDK9 | |
| SCHEMBL722250 | 0.85 | ACVR1 (0.51) | TGFBR1ACVR1CCNT1CDK9BMPR1A | |
| SCHEMBL723765 | 0.84 | ACVR1 (0.44) | USP8TGFBR1ACVR1CCNT1CDK9 | |
| SCHEMBL723929 | 0.83 | PIM1 (0.50) | CHRNB2CHRNA4MAPKAPK2TGFBR1ACVR1 | |
| SCHEMBL15209104 | 0.83 | MAPKAPK2 (0.48) | MAPKAPK2TGFBR1ACVR1CCNT1CDK9 | |
| SCHEMBL722093 | 0.82 | MAPKAPK2 (0.46) | MAPKAPK2TGFBR1ACVR1CDK9BMPR1A | |
| SCHEMBL15209552 | 0.79 | FGFR1 (0.41) | — | |
| SCHEMBL721482 | 0.79 | ACVR1 (0.44) | MAPKAPK2TGFBR1ACVR1CCNT1CDK9 | |
| SCHEMBL724976 | 0.78 | ACVR1 (0.44) | TGFBR1ACVR1CCNT1CDK9BMPR1A | |
| SCHEMBL15216705 | 0.78 | CHEK1 (0.47) | MAPKAPK2TGFBR1ACVR1CDK9BMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | claimed |
| EP-2609100-A2 | FUROPYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | claimed |
| WO-2012025187-A2 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | claimed |
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | disclosed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-20130225569-A1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225569-A1 | FUROPYRIDINE DERIVATIVES | SYK, FCGRT, SSB | CHRNB2 4829/4885CHRNA4 4844/4885MAPKAPK2 867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.