Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.39 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.38 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7237877 | 0.88 | TRPV1 (0.40) | TRPV1NPFFR1NPFFR2ABL1FGFR3 | |
| SCHEMBL7238630 | 0.87 | KDM4E (0.42) | NPFFR1NPFFR2 | |
| SCHEMBL7231945 | 0.87 | BACE1 (0.37) | TRPV1NPFFR1NPFFR2ABL1KDR | |
| SCHEMBL7236678 | 0.86 | SCN5A (0.46) | TRPV1 | |
| SCHEMBL7232510 | 0.86 | ATR (0.39) | NPFFR1NPFFR2TDP2RAB9A | |
| SCHEMBL7238421 | 0.85 | TRPV1 (0.43) | TRPV1NPFFR1NPFFR2PDK1PDK2 | |
| SCHEMBL7240032 | 0.84 | TRPV1 (0.45) | TRPV1NPFFR1NPFFR2RAB9A | |
| SCHEMBL7236713 | 0.83 | NPFFR1 (0.35) | TRPV1NPFFR1NPFFR2TDP2RAB9A | |
| SCHEMBL7237052 | 0.81 | NPFFR1 (0.37) | TRPV1NPFFR1NPFFR2 | |
| SCHEMBL7841418 | 0.80 | CYP17A1 (0.42) | TRPV1FGFR3KDRTDP2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521643-B1 | Prevention and/or treatment of nitric oxide synthasey medi-ated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, diabetes, ulcerative colitis, cerebral infarction, osteoarthritis | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-02-18 | — | — | US | disclosed |
| EP-1157022-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000049015-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-24 | — | — | WO | disclosed |